PCYT2

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Description

The PCYT2 (phosphate cytidylyltransferase 2, ethanolamine) is a protein-coding gene located on chromosome 17.

PCYT2 catalyzes the second step in the synthesis of phosphatidylethanolamine (PE) from ethanolamine via the CDP-ethanolamine pathway, which is involved in the production of PE, a major phospholipid in cell membranes. PE plays a role in maintaining membrane structure, stabilizing membrane-bound proteins, and participating in cellular processes like cell division, cell fusion, blood coagulation, and apoptosis.

PCYT2 is also known as ET, SPG82.

Associated Diseases

• Spastic paraplegia 82, autosomal recessive