PROC : protein C, inactivator of coagulation factors Va and VIIIa
Description
The PROC (protein C, inactivator of coagulation factors Va and VIIIa) is a protein-coding gene located on chromosome 2.
The PROC gene provides instructions for making a protein called protein C, which plays a crucial role in controlling blood clotting. Protein C inhibits the activity of two proteins, factor Va and factor VIIIa, that promote blood clot formation. It also participates in controlling inflammation, a natural bodily response to infections, irritation, or injury. Protein C is produced in the liver and released into the bloodstream. It remains inactive until it binds to a protein called thrombin, which activates it into activated protein C (APC). APC then breaks down factor Va at specific points, partially or completely inactivating it. This inactive form is called factor V. Finally, APC collaborates with factor V to inactivate factor VIIIa.
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. It also exerts a protective effect on the endothelial cell barrier function.
PROC is also known as APC, PC, PROC1, THPH3, THPH4.
Associated Diseases
- Thrombophilia, hereditary, due to protein C deficiency, autosomaldominant
- Thrombophilia due to protein C deficiency, autosomal recessive
- Severe hereditary thrombophilia due to congenital protein C deficiency
- Protein C deficiency
