PXDN
Description
The PXDN (peroxidasin) is a protein-coding gene located on chromosome 2.
PXDN is a human gene encoding a protein called peroxidasin homolog. This protein requires ionic bromine as a cofactor, making bromine an essential element for human life. Mutations in PXDN are linked to microphthalmia, a condition characterized by abnormally small eyes.
PXDN catalyzes the oxidation of bromide using hydrogen peroxide, generating hypobromite. This reactive intermediate forms sulfilimine cross-links between methionine and hydroxylysine residues in collagen IV, contributing to collagen IV network assembly and extracellular matrix signaling. These cross-links are crucial for endothelial cell growth and basement membrane integrity. PXDN also promotes angiogenesis and tubulogenesis through ERK1/2, Akt, and FAK pathways. It brominates alpha2 collagen IV chain at Tyr-1485, enriching basement membranes with bromine. PXDN can oxidize thiocyanate and iodide, which can inhibit sulfilimine bond formation. It binds laminins and may play a role in eye development.
PXDN is also known as ASGD7, COPOA, D2S448, D2S448E, MG50, PRG2, PXN, VPO, hsPxd01.
