SERPINE1
Description
The SERPINE1 gene encodes plasminogen activator inhibitor-1 (PAI-1), a crucial protein involved in regulating coagulation and fibrinolysis. PAI-1 inhibits the activity of tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), preventing the breakdown of fibrin clots and promoting thrombus formation. SERPINE1 plays a critical role in maintaining hemostasis and wound healing, but its dysregulation can contribute to various cardiovascular and thrombotic disorders.
Associated Diseases
- Venous thromboembolism (VTE)
- Coronary artery disease (CAD)
- Stroke
- Cancer
- Diabetes
- Obesity
- Metabolic syndrome
Did you know?
PAI-1 levels are influenced by various factors, including age, sex, lifestyle, and genetic predisposition.
