STAT5B
Description
The STAT5B (signal transducer and activator of transcription 5B) is a protein-coding gene located on chromosome 17.
STAT5B, or Signal transducer and activator of transcription 5B, is a protein encoded by the STAT5B gene in humans. It's a member of the STAT family of transcription factors, which are activated by cytokines and growth factors like IL2, IL4, CSF1, and growth hormones. STAT5B plays a crucial role in various biological processes, including TCR signaling, apoptosis, mammary gland development, and sex-specific liver gene expression. It's known to interact with several proteins including the glucocorticoid receptor, Janus kinases 1 and 2, and PTPN11. Dysregulation of STAT5B's signaling pathways can contribute to acute promyelocytic leukemias (APML).
STAT5B plays a key role in signal transduction and activation of transcription, responding to various growth factors, including KITLG/SCF. It binds to the GAS element, activating PRL-induced transcription and promoting hematopoietic/erythroid differentiation. This process is achieved through homo-dimer formation and interactions with other family members.
STAT5B is also known as GHISID2, STAT5.
Associated Diseases
- Acute promyelocytic leukemia
- Growth hormone insensitivity with immune dysregulation 1, autosomal recessive
- Growth hormone insensitivity with immune dysregulation 2, autosomal dominant
