FLJ44635
Title: Fibrinogen-Like Protein 2 (FGL2): A Multifaceted Player in Health and Disease
Description:
Fibrinogen-like protein 2 (FGL2), also known as fibrinogen-related protein-2, is a multifunctional protein involved in various biological processes, including hemostasis, inflammation, and tissue repair. It is produced primarily by hepatocytes in the liver and circulates in the bloodstream.
Associated Diseases:
FGL2 has been implicated in the pathogenesis of several diseases, including:
- Venous Thromboembolism (VTE): FGL2 levels are elevated in patients with VTE, a condition characterized by the formation of blood clots in the veins.
- Atherosclerosis: FGL2 contributes to the development of atherosclerosis, a buildup of plaque in the arteries that can lead to heart disease.
- Inflammation: FGL2 is a potent pro-inflammatory mediator involved in inflammatory diseases such as rheumatoid arthritis and sepsis.
- Cancer: FGL2 has been found to promote tumor growth and metastasis in various cancers, including breast cancer and liver cancer.
Did you Know ?
According to a study published in the journal "Blood," elevated FGL2 levels are associated with a 2-fold increased risk of developing VTE.
