FOSL2
Description
The FOSL2 (FOS like 2, AP-1 transcription factor subunit) is a protein-coding gene located on chromosome 2.
FOSL2, or Fos-related antigen 2, is a protein encoded by the FOSL2 gene in humans. It belongs to the Fos gene family, which includes c-Fos, FOSB, FOSL1, and FOSL2. These genes produce leucine zipper proteins capable of dimerizing with JUN family proteins, forming the AP-1 transcription factor complex. This complex is involved in regulating cell growth, differentiation, and transformation. FOSL2's function is primarily related to osteoclast survival and size regulation. It forms a dimer with JUN, activating LIF transcription. FOSL2 also activates CEBPB transcription in osteoblasts stimulated by PGE2. It interacts with components of the BAF chromatin-remodeling complex, including SMARCB1, SMARCD1, ARID1A, and JUN.
FOSL2 plays a role in regulating osteoclast survival and size. It forms a dimer with JUN, which activates LIF transcription. FOSL2 also activates CEBPB transcription in PGE2-activated osteoblasts.
FOSL2 is also known as ACED, FRA2.
