FUBP1
Description
The FUBP1 (far upstream element binding protein 1) is a protein-coding gene located on chromosome 1.
FUBP1 is a protein that in humans is encoded by the FUBP1 gene. This gene encodes a single-stranded DNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-strand binding of FUBP to the non-coding strand. This protein has been shown to function as an ATP-dependent DNA helicase. FUBP1 has been shown to interact with MAPK14 and SMN1. FUBP1 gene deletion forms part of the 1p/19q codeletion mutation seen in oligodendroglioma, a form of primary brain tumour. CIC gene is also lost in the 1p/19q codeletion mutation.
FUBP1 regulates the expression of the MYC gene by binding to a single-stranded far-upstream element (FUSE) located upstream of the MYC promoter. It can act as both an activator and a repressor of MYC transcription.
FUBP1 is also known as FBP, FUBP, hDH V.
Associated Diseases
- low grade glioma
- hemangioblastoma
- carcinoma of liver and intrahepatic biliary tract
- skin squamous cell carcinoma
- skin basal cell carcinoma
