FUT1
Description
The FUT1 (fucosyltransferase 1 (H blood group)) is a protein-coding gene located on chromosome 19.
Galactoside 2-alpha-L-fucosyltransferase 1 is an enzyme encoded by the FUT1 gene in humans. This enzyme is responsible for the synthesis of the H antigen.
FUT1 catalyzes the transfer of L-fucose from guanosine diphosphate-beta-L-fucose to the terminal galactose residue of glycoconjugates via an alpha(1,2) linkage, resulting in H antigen synthesis. This H antigen serves as an intermediate substrate in the production of ABO blood group antigens. Furthermore, H antigen plays a crucial role in the maturation of the glomerular layer of the main olfactory bulb, cell migration, and early cell-cell interactions during tumor-associated angiogenesis. FUT1 preferentially fucosylates soluble lactose and, to a lesser extent, glycolipids such as gangliosides GA1 and GM1a.
FUT1 is also known as H, HH, HSC.
