FXR2
Description
The FXR2 (FMR1 autosomal homolog 2) is a protein-coding gene located on chromosome 17.
FXR2 is a protein encoded by the FXR2 gene in humans. It is an RNA-binding protein with two KH domains and one RCG box, similar to FMRP and FXR1. FXR2 associates with polyribosomes, primarily with 60S large ribosomal subunits. It can self-associate or interact with FMRP and FXR1. FXR2 may play a role in the development of fragile X mental retardation syndrome.
FXR2 is an mRNA-binding protein that regulates the translation and/or stability of target mRNAs. It specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs, promoting the formation of phase-separated membraneless compartments. These compartments store mRNAs, regulating their translation and/or stability. FXR2 is also involved in adult hippocampal neurogenesis by regulating the translation and/or stability of NOG mRNA, preventing NOG protein expression in the dentate gyrus.
FXR2 is also known as FMR1L2, FXR2P.
