GBP4
Description
The GBP4 (guanylate binding protein 4) is a protein-coding gene located on chromosome 1.
GBP4 is an interferon-inducible GTPase that plays a crucial role in the innate immune system, defending against various bacterial, viral, and protozoan infections. GBP4 acts as a negative regulator of the antiviral response by suppressing the activation of the IRF7 transcription factor.
GBP4 is also known as Mpa2.
Associated Diseases
- cancer
- recurrent Neisseria infections due to factor D deficiency
- immunodeficiency 28
- isolated asymptomatic elevation of creatine phosphokinase
- varicella, severe recurrent
- candidiasis, familial, 4
- plasma fibronectin deficiency
- type II complement component 8 deficiency
- mannose-binding lectin deficiency
- immunodeficiency due to ficolin3 deficiency
- pentosuria
- myopathy due to calsequestrin and SERCA1 protein overload
