GCAT
Description
The GCAT (glycine C-acetyltransferase) is a protein-coding gene located on chromosome 22.
The GCAT gene encodes a protein known as glycine C-acetyltransferase. This enzyme plays a crucial role in the degradation of L-threonine to glycine. This process involves two steps, starting with the conversion of L-threonine into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. The GCAT gene encodes the second enzyme in this pathway, catalyzing the reaction between 2-amino-3-ketobutyrate and coenzyme A to produce glycine and acetyl-CoA. This enzyme is classified as a class II pyridoxal-phosphate-dependent aminotransferase. Multiple transcript variants are generated due to alternative splicing. A pseudogene of this gene is located on chromosome 14.
This enzyme requires pyridoxal phosphate (PLP) as a cofactor and catalyzes the breakdown of 2-amino-3-oxobutanoate, producing glycine and acetyl-CoA.
GCAT is also known as KBL.
