GCFC2
Description
The GCFC2 (GC-rich sequence DNA-binding factor 2) is a protein-coding gene located on chromosome 2.
The GCFC2 gene in humans encodes the GC-rich sequence DNA-binding factor protein. An initial mRNA transcript identified for this gene was an artificial chimera, created from two separate gene transcripts and a primer used in cloning. This chimera contained a positively charged amino terminus that was mistakenly believed to bind GC-rich DNA, leading to the misidentification of the gene as a transcription factor. However, further research has revealed that GCFC2 is actually a component of the Intron Large (IL) complex, a post-mRNA release spliceosomal complex. This complex contains the excised intron, U2, U5, and U6 snRNPs, and splicing factors. GCFC2 interacts with TFIP11 and DHX15 and plays a role in pre-mRNA splicing by regulating the formation of the spliceosome C complex. It may also contribute to late-stage splicing events and the turnover of excised introns.
GCFC2 contributes to pre-mRNA splicing by regulating the formation of the spliceosome C complex. It might also be involved in late-stage splicing events and the breakdown of excised introns.
GCFC2 is also known as C2orf3, DNABF, GCF, TCF9.
