GDE1
Description
The GDE1 (glycerophosphodiester phosphodiesterase 1) is a protein-coding gene located on chromosome 16.
GDE1 is an enzyme that breaks down glycerophosphodiesters, including glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), into glycerol phosphate and an alcohol. It also hydrolyzes glycerophospho-N-acylethanolamines in the brain, contributing to the production of bioactive N-acylethanolamines such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic). GDE1 exhibits lysophospholipase D activity, hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine. However, its lysophospholipase D activity is lower than its glycerophosphodiester phosphodiesterase activity. GDE1 has little or no activity towards glycerophosphocholine.
GDE1 is also known as 363E6.2, MIR16.
Associated Diseases
- glycogen storage disease due to lactate dehydrogenase H-subunit deficiency
- alcohol sensitivity, acute
- Brugada syndrome
- dehydrated hereditary stomatocytosis
- arrhythmogenic right ventricular dysplasia 10
- progressive familial heart block, type 1A
- cholesterol-ester transfer protein deficiency
- dilated cardiomyopathy 1E
- familial sick sinus syndrome
- hypertrophic cardiomyopathy 6
- familial pseudohyperkalemia
- hypertriglyceridemia 2
- Brugada syndrome 1
