GFRAL
Description
The GFRAL (GDNF family receptor alpha like) is a protein-coding gene located on chromosome 6.
GFRAL is a protein that in humans is encoded by the GFRAL gene.
GFRAL is a brainstem-restricted receptor for GDF15 that plays a crucial role in regulating food intake, energy expenditure, and body weight in response to metabolic and toxin-induced stresses. Upon binding to its ligand, GDF15, GFRAL interacts with RET, a tyrosine kinase receptor, leading to the activation of MAPK- and AKT- signaling pathways.
GFRAL is also known as C6orf144, GRAL, UNQ9356, bA360D14.1.
Associated Diseases
- obesity due to melanocortin 4 receptor deficiency
- severe early-onset obesity-insulin resistance syndrome due to SH2B1 deficiency
- obesity due to leptin receptor gene deficiency
- obesity due to SIM1 deficiency
- glycogen storage disease VI
- cancer
