GGH
Description
The GGH (gamma-glutamyl hydrolase) is a protein-coding gene located on chromosome 8.
GGH can refer to the human gene GGH.
GGH hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates, progressively removing gamma-glutamyl residues to produce pteroyl-alpha-glutamate (folic acid) and free glutamate. This enzyme plays a crucial role in the bioavailability of dietary pteroylpolyglutamates and the metabolism of pteroylpolyglutamates and antifolates.
GGH is also known as GATD10, GH.
Associated Diseases
- cancer
- substance abuse
- Mayer-Rokitansky-Kuster-Hauser syndrome
- 46,XX ovotesticular disorder of sex development
- testicular agenesis
- 46,XY complete gonadal dysgenesis
- 46,XY sex reversal 3
