GLCE
Description
The GLCE (glucuronic acid epimerase) is a protein-coding gene located on chromosome 15.
The GLCE gene encodes D-glucuronyl C5-epimerase, an enzyme involved in human biology.
The GLCE gene encodes an enzyme that converts D-glucuronic acid residues to L-iduronic acid residues in maturing heparan sulfate (HS) and heparin chains. This conversion occurs specifically adjacent to N-sulfate sugar residues and is essential for further modifications that define the specificity of interactions between these glycosaminoglycans and proteins.
GLCE is also known as HSEPI.
Associated Diseases
- Eiken syndrome
- congenital absence of upper arm and forearm with hand present
- Jeune syndrome
- metatropic dysplasia
- polydactyly, postaxial, type A1
