GPR173
Description
The GPR173 (G protein-coupled receptor 173) is a protein-coding gene located on chromosome X.
GPR173 is a protein that is encoded by the GPR173 gene in humans. It is a probable G-protein coupled receptor.
GPR173 is a receptor for the SMIM20-derived peptides Phoenixin-14 and Phoenixin-20. It mediates the augmentation of gonadotropin-releasing hormone (GnRH) signaling by these peptides in the hypothalamus and pituitary gland. In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 on granulosa cell proliferation during follicular growth.
GPR173 is also known as SREB3.
Associated Diseases
- acroleukopathy, symmetric
- familial generalized lentiginosis
- linear atrophoderma of Moulin
- Dowling-Degos disease 1
- familial progressive hyperpigmentation
- dyschromatosis symmetrica hereditaria
- hyperpigmentation with or without hypopigmentation, familial progressive
- schizophrenia 15
- Phelan-McDermid syndrome
- tufted angioma
- Potocki-Lupski syndrome
