GPR174
Description
The GPR174 (G protein-coupled receptor 174) is a protein-coding gene located on chromosome X.
GPR174, also known as Probable G-protein coupled receptor 174, is a protein encoded by the GPR174 gene in humans.
GPR174 is a G protein-coupled receptor for lysophosphatidylserine (LysoPS) that plays a role in immune response. It downregulates regulatory T-cell activity, suppresses IL-2 production in activated T-lymphocytes, and contributes to macrophage polarization during sepsis. Upon testosterone treatment, it acts as a receptor for CCL21, triggering calcium flux and promoting CD86 upregulation in follicular B-cells.
GPR174 is also known as FKSG79, GPCR17, LPS3, LYPSR3.
Associated Diseases
- C1 inhibitor deficiency
- common variable immunodeficiency
- inborn error of immunity
- autosomal systemic lupus erythematosus type 16
- severe combined immunodeficiency due to CARD11 deficiency
- severe combined immunodeficiency due to CTPS1 deficiency
- immunodeficiency 18
- autoimmune lymphoproliferative syndrome
- reticular dysgenesis
- combined immunodeficiency with skin granulomas
- immunodeficiency 25
- complement component C1s deficiency
- Wiskott-Aldrich syndrome
