GPR34
Description
The GPR34 (G protein-coupled receptor 34) is a protein-coding gene located on chromosome X.
GPR34 is a protein encoded by the GPR34 gene in humans. It is a G-protein coupled receptor (GPCR) with 7 transmembrane domains, which are characteristic of this type of receptor.
GPR34 is a G-protein coupled receptor that binds lysophosphatidylserine (LysoPS) and plays a crucial role in immune response. It acts as a damage-sensing receptor, triggering tissue repair when it detects dying neutrophils. This occurs through the recognition of lysophosphatidylserine released by apoptotic neutrophils by type 3 innate lymphoid cells (ILC3s) via GPR34. This interaction activates signaling pathways (PI3K-AKT and RAS-ERK) leading to STAT3 activation and the production of IL-22. GPR34 is also important for microglial function, influencing their morphology and phagocytic activity.
GPR34 is also known as LPS1, LYPSR1.
Associated Diseases
- hyper-IgE recurrent infection syndrome 5, autosomal recessive
- adult acute respiratory distress syndrome
- FADD-related immunodeficiency
- persistent truncus arteriosus
- cancer
- glioblastoma
- pancreatic ductal adenocarcinoma
