GPR83
Description
The GPR83 (G protein-coupled receptor 83) is a protein-coding gene located on chromosome 11.
Probable G-protein coupled receptor 83 is a protein encoded by the GPR83 gene in humans.
GPR83 acts as a G-protein coupled receptor for PEN, a neuropeptide derived from the proSAAS precursor protein encoded by the PCSK1N gene. This receptor functions through a G(i)- and G(q)-alpha-alpha-mediated pathway in response to PEN (PMID:27117253), playing a role in regulating food intake and body weight. It is also suggested to contribute to the regulation of anxiety-related behaviors.
GPR83 is also known as GIR, GPR72.
Associated Diseases
- Potocki-Lupski syndrome
- schizophrenia 15
- intellectual disability, autosomal dominant 50
- Phelan-McDermid syndrome
- erythroleukemia, familial, susceptibility to
- immunodeficiency 76
- glycoprotein storage disease
- FRAXE intellectual disability
- combined immunodeficiency due to OX40 deficiency
- hemoglobin H disease
