GSDMD
Description
The GSDMD (gasdermin D) is a protein-coding gene located on chromosome 8.
Gasdermin D (GSDMD) is a protein encoded by the GSDMD gene on chromosome 8 in humans. It belongs to the gasdermin family, a group of proteins found in vertebrates that are involved in various cellular processes, including immune responses and cell death. GSDMD is composed of two domains: the N-terminal domain (GSDMD-N) and the C-terminal domain (GSDMD-C), connected by a linker region. The structure of GSDMD-C includes 10 α-helices and two β-strands, forming a compact globular fold. GSDMD-N plays a crucial role in pyroptosis, a type of inflammatory cell death. Upon activation, GSDMD is cleaved by inflammatory caspases, releasing GSDMD-N, which then binds to cell membranes. GSDMD-N forms pores in the membrane, allowing the release of inflammatory cytokines like IL-1β and IL-18, and ultimately leading to cell death. These pores can also be formed in mitochondrial membranes, resulting in the release of mitochondrial DNA into the cytosol. GSDMD-N has also been shown to kill bacteria without harming neighboring mammalian cells.
Gasdermin-D, also known as Gasdermin domain-containing protein 1, is the precursor of a pore-forming protein that plays a critical role in host defense against pathogen infection and danger signals. Upon cleavage, the released N-terminal fragment (Gasdermin-D, N-terminal) binds to membranes and forms pores, triggering pyroptosis.
GSDMD is also known as DF5L, DFNA5L, FKSG10, GSDMDC1.
