PDCD7
Description
The PDCD7 (programmed cell death 7) is a protein-coding gene located on chromosome 15.
Programmed cell death protein 7 is a protein encoded by the PDCD7 gene in humans. It shares sequence similarity with a mouse protein initially identified in embryonic stem cells. In mouse T-cell lines, this protein is involved in apoptotic pathways triggered by glucocorticoids and staurine, and is linked to ceramide-mediated signaling. These observations suggest its role in specific apoptotic processes within T-cells.
PDCD7 is also known as 59K, ES18, HES18.
Associated Diseases
- nanophthalmia
- nanophthalmos 2
- dehydrated hereditary stomatocytosis
- sideroblastic anemia 3
- congenital dyserythropoietic anemia type 4
- hemochromatosis type 2B
- dominant beta-thalassemia
- severe congenital hypochromic anemia with ringed sideroblasts
- hemoglobin D disease
- trimethylaminuria
- pyruvate kinase deficiency of red cells
- non-spherocytic hemolytic anemia due to hexokinase deficiency
- Rh deficiency syndrome
