PDE9A
Description
The PDE9A (phosphodiesterase 9A) is a protein-coding gene located on chromosome 21.
PDE9A, encoded by the PDE9A gene in humans, is an enzyme that breaks down cAMP and cGMP into their monophosphate forms. It plays a role in cell signaling by controlling the levels of these cyclic nucleotides. This gene produces multiple transcript variants, resulting in several different protein isoforms.
PDE9A specifically breaks down cGMP, a crucial signaling molecule involved in various biological processes. It exhibits high affinity and selectivity for cGMP compared to other phosphodiesterases (PubMed:9624146, PubMed:18757755, PubMed:21483814). In the heart, PDE9A specifically regulates cGMP signaling triggered by natriuretic peptides, acting as a controller of cardiac hypertrophy in muscle cells (PubMed:25799991). However, it does not regulate nitric oxide-dependent cGMP signaling in the heart. Further research is needed to determine if PDE9A's ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to the heart or a general property of the protein. In the brain, PDE9A is implicated in cognitive functions such as learning and memory (By similarity). {ECO:0000250|UniProtKB:Q8QZV1, ECO:0000269|PubMed:18757755, ECO:0000269|PubMed:21483814, ECO:0000269|PubMed:25799991, ECO:0000269|PubMed:9624146, ECO:0000305}
PDE9A is also known as HSPDE9A2.
