PFDN2
Description
The PFDN2 (prefoldin subunit 2) is a protein-coding gene located on chromosome 1.
Prefoldin subunit 2 is a protein that in humans is encoded by the PFDN2 gene. This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.
Prefoldin subunit 2 (PFDN2) acts as a molecular chaperone by binding to newly synthesized polypeptide chains, promoting their correct folding and facilitating their transfer to the cytosolic chaperonin (c-CPN) for further processing.
PFDN2 is also known as PFD2.
Associated Diseases
- esophageal cancer
- Gorham-Stout disease
- melorheostosis
- cancer
- type 2 diabetes mellitus
- urinary bladder carcinoma
- Alzheimer disease
- COVID-19
