PJA2
Description
The PJA2 (praja ring finger ubiquitin ligase 2) is a protein-coding gene located on chromosome 5.
PJA2, also known as Praja2, is a human protein encoded by the PJA2 gene. It is an E3 ubiquitin-protein ligase, an enzyme that catalyzes the attachment of ubiquitin to target proteins. PJA2 has been shown to interact with UBE2D2, a ubiquitin-conjugating enzyme.
PJA2 functions as an E3 ubiquitin-protein ligase, requiring an E2 enzyme for activity. It ubiquitinates and targets cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits for proteasomal degradation, playing a key role in PKA-mediated long-term memory processes. Additionally, PJA2 ubiquitinates MFHAS1, positively regulating the TLR2 signaling pathway, leading to the activation of p38 and JNK MAP kinases and promoting macrophage polarization toward the pro-inflammatory M1 phenotype. PJA2 is also involved in ciliogenesis by ubiquitinating OFD1.
PJA2 is also known as Neurodap1, RNF131.
Associated Diseases
- alcohol-related disorders
- familial idiopathic steroid-resistant nephrotic syndrome
- neuronal ceroid lipofuscinosis 1
- congenital nephrotic syndrome, Finnish type
- focal segmental glomerulosclerosis 7
- renal hypoplasia
- C3 glomerulonephritis
- nephrotic syndrome, type 4
