PLAGL2
Description
The PLAGL2 (PLAG1 like zinc finger 2) is a protein-coding gene located on chromosome 20.
PLAGL2 gene encodes Zinc finger protein PLAGL2, a protein that binds to DNA and/or RNA. In gliomas, PLAGL2 suppresses cellular differentiation, promoting stem cell-like characteristics. This plasticity in glioma cells makes them resistant to differentiation factors.
PLAGL2 is also known as ZNF900.
Associated Diseases
- cancer
- congenital diarrhea 7 with exudative enteropathy
- chylomicron retention disease
- glycogen storage disease VI
