PLEKHF2
Description
The PLEKHF2 (pleckstrin homology and FYVE domain containing 2) is a protein-coding gene located on chromosome 8.
PLEKHF2 is a protein encoded by the PLEKHF2 gene in humans. It is a member of the Pleckstrin homology domain-containing family F.
PLEKHF2 may play a role in early endosome fusion upstream of RAB5, which regulates receptor trafficking and fluid-phase transport. It also enhances cellular sensitivity to TNF-induced apoptosis (PMID:18288467).
PLEKHF2 is also known as EAPF, PHAFIN2, ZFYVE18.
