PLXNB3
Description
The PLXNB3 (plexin B3) is a protein-coding gene located on chromosome X.
Plexin-B3 is a protein encoded by the PLXNB3 gene in humans. It interacts with ARHGEF11.
PLXNB3 is a receptor for SEMA5A, involved in axon guidance, invasive growth, and cell migration. It stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A activation of PLXNB3 leads to the breakdown of F-actin stress fibers, disruption of focal adhesions, and cellular collapse, ultimately inhibiting cell migration and invasion through ARHGDIA-mediated inactivation of RAC1.
PLXNB3 is also known as PLEXB3, PLEXR, PLXN6.
Associated Diseases
- thyroid gland adenocarcinoma
- pachyonychia congenita
- cancer
- pancreatic ductal adenocarcinoma
- microphthalmia with limb anomalies
