PNLIPRP2
Description
The PNLIPRP2 (pancreatic lipase related protein 2 (gene/pseudogene)) is a protein-coding gene located on chromosome 10.
PNLIPRP2 is a human gene.
PNLIPRP2 is a lipase that primarily hydrolyzes triglycerides and galactosylglycerides. In neonates, it plays a major role in pancreatic digestion of dietary fats, particularly milk fat globules enriched in long-chain triglycerides. PNLIPRP2 hydrolyzes short-, medium-, and long-chain fatty acyls in triglycerides without positional specificity and can completely deacylate triacylglycerols. As the liver matures and bile salt synthesis increases, PNLIPRP2 likely functions mainly as a galactolipase and monoacylglycerol lipase. It hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids. PNLIPRP2 also hydrolyzes medium- and long-chain fatty acyls in galactolipids and may act together with LIPF to hydrolyze partially digested triglycerides. It efficiently hydrolyzes long-chain monoglycerides. In cytotoxic T cells, PNLIPRP2 contributes to perforin-dependent cell lysis, but it is unlikely to mediate direct cytotoxicity. PNLIPRP2 also exhibits low phospholipase activity. In neurons, PNLIPRP2 is required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids. The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4, promoting surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane.
PNLIPRP2 is also known as PLRP2.
Associated Diseases
- esophageal cancer
- autoimmune lymphoproliferative syndrome type 2B
- acrocephalopolysyndactyly
- cancer
- type 1 diabetes mellitus
- pancreatic ductal adenocarcinoma
- mastocytoma
- type 2 diabetes mellitus
