PPP2CB
Description
The PPP2CB (protein phosphatase 2 catalytic subunit beta) is a protein-coding gene located on chromosome 8.
The PPP2CB gene encodes the beta isoform of the catalytic subunit of protein phosphatase 2A (PP2A), a major serine/threonine phosphatase involved in regulating cell growth and division. PP2A comprises a core enzyme consisting of a catalytic subunit and a regulatory subunit, and it interacts with various regulatory subunits. This gene encodes the beta isoform of the catalytic subunit.
The protein encoded by PPP2CB, PP2A-beta, is a catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase that plays a crucial role in regulating various cellular processes, including enzyme activity, signal transduction, and cellular events. PP2A has been shown to modulate the activity of several kinases, including phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
PPP2CB is also known as PP2Abeta, PP2CB.
Associated Diseases
- cancer
- esophageal cancer
- macular corneal dystrophy
- X-linked retinal dysplasia
- snowflake vitreoretinal degeneration
- corneal endothelial dystrophy
- severe early-childhood-onset retinal dystrophy
- keratoconus 1
- X-linked endothelial corneal dystrophy
