PPP4R1
Description
The PPP4R1 (protein phosphatase 4 regulatory subunit 1) is a protein-coding gene located on chromosome 18.
PPP4R1 (Serine/threonine-protein phosphatase 4 regulatory subunit 1) is an enzyme encoded by the PPP4R1 gene in humans.
PPP4R1 is a regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). It may play a role in cell division regulation in kidney glomeruli. The PPP4C-PPP4R1 complex is thought to be involved in dephosphorylation and regulation of HDAC3.
PPP4R1 is also known as MEG1, PP4(Rmeg), PP4R1.
Associated Diseases
- Parkinson disease
- multiple sclerosis
- Alzheimer disease
- lysosomal storage disease
- type 2 diabetes mellitus
- cancer
- osteomesopyknosis
- osteosclerosis-ichthyosis-premature ovarian failure syndrome
- dacryocystitis-osteopoikilosis syndrome
- familial hyperprolactinemia
- ghosal hematodiaphyseal dysplasia
- melorheostosis
- male infertility with teratozoospermia due to single gene mutation
