PRAP1
Description
The PRAP1 (proline rich acidic protein 1) is a protein-coding gene located on chromosome 10.
Proline rich acidic protein 1 is a protein that in humans is encoded by the PRAP1 gene.
PRAP1 is a lipid-binding protein that promotes lipid absorption by facilitating MTTP-mediated lipid transfer (mainly triglycerides and phospholipids) and MTTP-mediated apoB lipoprotein assembly and secretion. It protects the gastrointestinal epithelium from irradiation-induced apoptosis. PRAP1 may play an important role in maintaining normal growth homeostasis in epithelial cells. It is involved in p53/TP53-dependent cell survival after DNA damage. PRAP1 may down-regulate the expression of MAD1L1 and exert a suppressive role in mitotic spindle assembly checkpoint in hepatocellular carcinomas. It interacts with isoform 1 and isoform 3 of MAD1L1. It interacts with MTTP.
PRAP1 is also known as PRO1195, UPA.
Associated Diseases
- immune deficiency, familial variable
- hyper-IgM syndrome type 3
- classic Hodgkin lymphoma
- hyper-IgM syndrome type 2
- hyper-IgM syndrome type 5
- immunodeficiency, common variable, 14
- severe combined immunodeficiency due to CARD11 deficiency
- immunodeficiency, common variable, 7
- immunodeficiency, common variable, 4
- BENTA disease
- IgE responsiveness, atopic
- severe combined immunodeficiency due to CTPS1 deficiency
