PRM2
Description
The PRM2 (protamine 2) is a protein-coding gene located on chromosome 16.
Protamine 2 is a protein encoded by the PRM2 gene in humans. Protamines replace histones in the chromatin of sperm during the haploid phase of spermatogenesis, and are the major DNA-binding proteins in the nucleus of sperm in many vertebrates. They package the sperm DNA into a highly condensed complex in a volume less than 5% of a somatic cell nucleus. Many mammalian species have only one protamine (protamine 1); however, a few species, including human and mouse, have two. This gene encodes protamine 2, which is cleaved to give rise to a family of protamine 2 peptides. Alternatively spliced transcript variants have also been found for this gene.
Protamines replace histones in the sperm chromatin during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
PRM2 is also known as CT94.2.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- spermatogenic failure 72
- spermatogenic failure 27
- spermatogenic failure 18
- spermatogenic failure 46
- spermatogenic failure 65
- spermatogenic failure 49
- spermatogenic failure 45
- spermatogenic failure 19
- spermatogenic failure 43
- spermatogenic failure 42
- spermatogenic failure, X-linked, 3
- spermatogenic failure 40
- spermatogenic failure 39
- spermatogenic failure 47
- spermatogenic failure 10
- spermatogenic failure 11
- spermatogenic failure 41
- spermatogenic failure 51
- spermatogenic failure 20
