PRMT8
Description
The PRMT8 (protein arginine methyltransferase 8) is a protein-coding gene located on chromosome 12.
PRMT8 is a protein that in humans is encoded by the PRMT8 gene. Arginine methylation is a posttranslational modification involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, and protein compartmentalization. PRMT8 binds and dimethylates Ewing sarcoma breakpoint region 1 (EWS) protein.
PRMT8 is an S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that catalyzes the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A, and H2A/H2B dimer. It can also mono- and dimethylate EWS protein, but its precise role in this interaction remains unclear as it interacts with fully methylated EWS.
PRMT8 is also known as HRMT1L3, HRMT1L4.
Associated Diseases
- early-onset non-syndromic cataract
- isolated ectopia lentis
- hereditary hyperferritinemia with congenital cataracts
