PSG2
Description
The PSG2 (pregnancy specific beta-1-glycoprotein 2) is a protein-coding gene located on chromosome 19.
PSG2 is a member of the pregnancy-specific glycoprotein (PSG) family, which are proteins produced by the placental trophoblast during pregnancy and released into the maternal bloodstream. The PSG family is a subset of the carcinoembryonic antigen (CEA) gene family, part of the immunoglobulin superfamily. These proteins consist of an N-domain similar to the immunoglobulin variable domain, followed by multiple constant immunoglobulin-like A and/or B domains. Most PSG proteins, including PSG2, possess the Argglyasp (RGD) motif in their N-terminal domain, which functions as an adhesion recognition signal for integrins.
Pregnancy-specific glycoprotein 2 (PSG2) belongs to the carcinoembryonic antigen (CEA) gene family, which is part of the immunoglobulin superfamily. It contains a variable domain (N-domain) similar to immunoglobulin, followed by multiple immunoglobulin-like A and/or B domains. The N-terminal domain has an Argglyasp (RGD) motif, known to interact with integrins as an adhesion recognition signal.
PSG2 is also known as CEA, PSBG2, PSG1.
