PSME2
Description
The PSME2 (proteasome activator subunit 2) is a protein-coding gene located on chromosome 14.
The PSME2 gene encodes Proteasome activator complex subunit 2, a protein vital for the function of the 26S proteasome, a complex responsible for protein degradation in cells. The 26S proteasome consists of a 20S core, composed of 28 subunits, and a 19S regulator. PSME2 is part of the 11S regulator, also known as PA28, which is an alternative regulator that can replace the 19S regulator in a modified proteasome called the immunoproteasome. The immunoproteasome is crucial for processing peptides that bind to class I MHC molecules, a key step in the immune response. PSME2, as the beta subunit of the 11S regulator, is induced by gamma-interferon and forms a heterohexameric ring with three alpha subunits, contributing to the assembly of the immunoproteasome.
PSME2 is also known as PA28B, PA28beta, REGbeta.
Associated Diseases
- cancer
- adamantinoma
- cervical cancer
- nonpapillary renal cell carcinoma
- severe combined immunodeficiency due to CARD11 deficiency
- breast cancer
