PVRIG
Description
The PVRIG (PVR related immunoglobulin domain containing) is a protein-coding gene located on chromosome 7.
PVRIG (Poliovirus receptor related immunoglobulin domain containing) is a protein encoded by the PVRIG gene in humans.
PVRIG is a cell surface receptor that binds to NECTIN2. It can act as a coinhibitory receptor, suppressing T-cell receptor signals and inhibiting T-cell proliferation upon interaction with NECTIN2. PVRIG competes with CD226 for binding to NECTIN2.
PVRIG is also known as C7orf15, CD112R.
Associated Diseases
- cancer
- hyper-IgM syndrome type 3
- severe combined immunodeficiency due to CARD11 deficiency
- reticular dysgenesis
- Wiskott-Aldrich syndrome
- severe combined immunodeficiency due to CTPS1 deficiency
- immunodeficiency 75
