REV1
Description
The REV1 (REV1 DNA directed polymerase) is a protein-coding gene located on chromosome 2.
REV1 is a DNA repair protein encoded by the REV1 gene in humans. It shares similarity with the S. cerevisiae mutagenesis protein Rev1 and contains a BRCT domain, which is important for protein-protein interactions. REV1 acts as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. It is a Y family DNA polymerase, also known as a deoxycytidyl transferase because it specifically inserts deoxycytidine (dC) opposite lesions. REV1 always adds a C, regardless of the base opposite it (G, A, T, C, or an abasic site), by using an arginine as a template. While REV1 possesses polymerase activity, its primary role is believed to be in recruiting TLS proteins, particularly Pol ζ (Rev3/Rev7). REV1 interacts with MAD2L2.
REV1 is a deoxycytidyl transferase involved in DNA repair. It transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. REV1 may assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. REV1 is required for normal induction of mutations by physical and chemical agents.
REV1 is also known as AIBP80, REV1L.
Associated Diseases
- low grade glioma
- cancer
- neutropenia, severe congenital, 2, autosomal dominant
- peptic ulcer disease
- combined immunodeficiency with skin granulomas
