RHOJ
Description
The RHOJ (ras homolog family member J) is a protein-coding gene located on chromosome 14.
Rho-related GTP-binding protein RhoJ is a protein that in humans is encoded by the RHOJ gene. ARHJ belongs to the Rho family of small GTP-binding proteins. Rho proteins regulate the dynamic assembly of cytoskeletal components for several physiologic processes, such as cell proliferation and motility and the establishment of cell polarity.
RhoJ is a small GTPase that plays a critical role in angiogenesis, the formation of new blood vessels. It is specifically involved in endothelial cell migration, a crucial process for vascular development. RhoJ interacts with GLUL, a protein essential for endothelial cell migration. RhoJ's function involves eliciting the formation of F-actin-rich structures, which regulate endothelial cell migration. These findings are supported by several scientific studies (PubMed:21628409, PubMed:24434213, PubMed:30158707).
RHOJ is also known as ARHJ, RASL7B, TC10B, TCL.
Associated Diseases
- ptosis
- X-linked retinal dysplasia
- severe early-childhood-onset retinal dystrophy
- age related macular degeneration 11
- age related macular degeneration 7
- age related macular degeneration 4
- coloboma of optic nerve
- exudative vitreoretinopathy 2, X-linked
- congenital factor X deficiency
- urinary bladder carcinoma
- cancer
