RNASE2
Description
The RNASE2 (ribonuclease A family member 2) is a protein-coding gene located on chromosome 14.
RNASE2 encodes a protein found in eosinophil granulocytes, a type of white blood cell. This protein is closely related to eosinophil cationic protein (RNASE3) and likely diverged from it around 50 million years ago. It has a neutral charge and possesses cytotoxic properties, meaning it can kill cells. RNASE2 can also reduce the activity of single-stranded RNA viruses in cultures through its enzymatic activity. Additionally, it attracts immune cells.
RNASE2 is a non-secretory ribonuclease, specifically targeting pyrimidines with a slight preference for uracil. It acts as a cytotoxin and helminthotoxin, and selectively attracts dendritic cells. Its diverse functions are supported by evidence from various studies (PubMed:12578357, PubMed:3458170).
RNASE2 is also known as EDN, RAF3, RNS2.
Associated Diseases
- Bartsocas-Papas syndrome 1
- Ehlers-Danlos syndrome, musculocontractural type
- nonpapillary renal cell carcinoma
