RNASE6
Description
The RNASE6 (ribonuclease A family member 6) is a protein-coding gene located on chromosome 14.
The RNASE6 gene encodes a protein belonging to the ribonuclease A superfamily. It plays a role in the urinary tract and exhibits broad-spectrum antimicrobial activity against pathogenic bacteria.
RNASE6, also known as Ribonuclease K6, exhibits a preference for the pyrimidines uridine and cytosine. It demonstrates potent antibacterial activity against a broad range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli. The mechanism of action involves disrupting bacterial membrane integrity and promoting agglutination of Gram-negative bacteria. This activity is independent of its RNase activity. RNASE6 likely contributes to urinary tract sterility by its antibacterial properties. It interacts with bacterial lipopolysaccharide (LPS) via its N-terminus.
RNASE6 is also known as RAD1, RNS6, RNasek6.
Associated Diseases
- endometrial cancer
- bacterial urinary tract infection
- chronic intestinal pseudoobstruction
- neutropenia, severe congenital, 2, autosomal dominant
- 46,XX ovotesticular disorder of sex development
- tetragametic chimerism
- Miyoshi myopathy
- pancreatic ductal adenocarcinoma
