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The RNF181 (ring finger protein 181) is a protein-coding gene located on chromosome 2.
RNF181 acts as an E3 ubiquitin ligase, accepting ubiquitin from E2 enzymes and transferring it to target proteins. It specifically monoubiquitinates the PSMC2/RPT1 subunit of the 26S proteasome.
RNF181 is also known as HSPC238.
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