RTCA
Description
The RTCA (RNA 3'-terminal phosphate cyclase) is a protein-coding gene located on chromosome 1.
RTCA may refer to: RNA 3'-terminal phosphate cyclase (RNA cyclase), RNA-3'-phosphate cyclase, or RNA terminal phosphate cyclase domain-containing protein 1.
RTCA catalyzes the conversion of a 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA, a process essential for RNA processing. This enzyme's mechanism involves three steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. RTCA is likely involved in various aspects of cellular RNA processing and plays a crucial role in regulating axon regeneration, specifically by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury.
RTCA is also known as RPC, RTC1, RTCD1.
