SACM1L
Description
The SACM1L (SAC1 like phosphatidylinositide phosphatase) is a protein-coding gene located on chromosome 3.
Phosphatidylinositide phosphatase SAC1 is an enzyme that in humans is encoded by the SACM1L gene.
SACM1L is a phosphoinositide phosphatase that catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P). It can also hydrolyze phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). SACM1L exhibits robust PtdIns(4)P phosphatase activity when bound to PtdIns(4)P in a 'cis' configuration within the cellular environment, with significantly lower activity observed when bound in a 'trans' configuration. The 'trans' configuration activity is enhanced in the presence of PLEKHA3.
SACM1L is also known as SAC1.
