SART1
Description
The SART1 (spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP) is a protein-coding gene located on chromosome 11.
The SART1 gene encodes two proteins: SART1(800), found in the nucleus of proliferating cells, and SART1(259), located in the cytosol of epithelial cancers. The latter protein is produced by -1 frameshifting during post-transcriptional regulation. Both proteins are involved in regulating proliferation and contain tumor-rejection antigens. The SART1(259) protein has tumor epitopes that can activate cytotoxic T lymphocytes in cancer patients, making it a potential target for immunotherapy. It may also be useful for diagnosing and treating patients with atopy. Notably, SART1(259) is crucial for recruiting the tri-snRNP to the pre-spliceosome during spliceosome assembly.
SART1 plays a crucial role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, a key structure within the spliceosome. Additionally, it has the potential to bind to DNA.
SART1 is also known as Ara1, HAF, HOMS1, SART1259, SNRNP110, Snu66.
