SCRT1

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Description

The SCRT1 (scratch family transcriptional repressor 1) is a protein-coding gene located on chromosome 8.

SCRT1 is a transcriptional repressor that binds to the E-box motif CAGGTG. This binding allows it to modulate the activity of basic helix-loop-helix (bHLH) transcription factors, which are crucial for neuronal differentiation.

SCRT1 is also known as SCRT, ZNF898.

Associated Diseases

• type 2 diabetes mellitus
• cancer
• neuroendocrine carcinoma
• pachyonychia congenita