SDC1
Description
The SDC1 (syndecan 1) is a protein-coding gene located on chromosome 2.
Syndecan-1 is a transmembrane protein encoded by the SDC1 gene. It's a member of the syndecan proteoglycan family and acts as a receptor for extracellular matrix proteins, playing a role in cell proliferation, migration, and cell-matrix interactions. It binds growth factors and chemokines via its heparan sulfate chains, influencing cell signaling, cytoskeletal organization, and cell binding. Syndecan-1 is involved in internalizing the HIV-1 tat protein and is implicated in various tumor types. It can also serve as a marker for plasma cells. The protein consists of an extracellular domain, a transmembrane domain, and a cytoplasmic domain. The extracellular domain can be cleaved from the cell surface, releasing it as a paracrine effector molecule. This shedding process contributes to wound repair and invasive growth in cancer cells. The protein binds to mitogen lacritin only after heparanase modification.
Syndecan-1 is a cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate. It connects the cytoskeleton to the interstitial matrix and plays a role in regulating exosome biogenesis. Syndecan-1 also induces its own expression in dental mesenchymal cells and neighboring dental epithelial cells through an MSX1-mediated pathway.
SDC1 is also known as CD138, SDC, SYND1, syndecan.
