SEC14L1
Description
The SEC14L1 (SEC14 like lipid binding 1) is a protein-coding gene located on chromosome 17.
SEC14-like protein 1 is a protein encoded by the SEC14L1 gene in humans. It belongs to the SEC14 cytosolic factor family and shares similarities with yeast SEC14 and Japanese flying squid RALBP, suggesting a possible role in intracellular transport.
SEC14L1 plays a role in innate immunity by suppressing the antiviral RIG-I signaling pathway. It acts as a negative regulator of RIGI, a sensor of viral nucleic acids in the cytoplasm, by preventing RIGI's interaction with MAVS/IPS1, a crucial step in signal propagation. SEC14L1 may also regulate the SLC18A3 and SLC5A7 cholinergic transporters.
SEC14L1 is also known as PRELID4A, SEC14L.
Associated Diseases
- Alzheimer disease
- Parkinson disease
- multiple sclerosis
- lysosomal storage disease
- diabetes mellitus, permanent neonatal 4
- diabetes mellitus, transient neonatal, 3
- permanent neonatal diabetes mellitus 1
- cancer
- COVID-19
