SEC23IP
Description
The SEC23IP (SEC23 interacting protein) is a protein-coding gene located on chromosome 10.
SEC23-interacting protein is a protein encoded by the SEC23IP gene. It plays a role in protein transport from the Endoplasmic Reticulum to the Golgi Apparatus by interacting with COPII-coated vesicles. It shares similarities with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1. Overexpression of SEC23IP can disrupt the organization of the endoplasmic reticulum-Golgi intermediate compartment and the Golgi apparatus, indicating its involvement in the early secretory pathway.
SEC23IP plays a role in organizing endoplasmic reticulum exit sites. It specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P).
SEC23IP is also known as MSTP053, P125, P125A, iPLA1A, iPLA1beta.
Associated Diseases
- type 2 diabetes mellitus
- male infertility with teratozoospermia due to single gene mutation
- partial chromosome Y deletion
- spermatogenic failure 20
- spermatogenic failure 42
- spermatogenic failure 5
- spermatogenic failure 72
